We didn't find the need to change anything. The fueling system has plenty of headroom. We've also tested other Audi platforms on E85 for several years straight and have found no need to change fuel lines.Not that I would touch this car but to run the R8 on E85 does anything need to be changed? Would be good to know for those who are considering it (plus I'm curious). Fuel lines? Injectors? etc.